Natural compound DOCA blocks TNF-α/TNFR-driven NF-κB activation to ameliorate rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disorder that has long been hampered by limited treatment efficacy and significant side effects. Tumor necrosis factor-α (TNF-α) plays a pivotal role in RA pathogenesis by binding to its receptor (TNFR) and activating the downstream nuclear...

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Principais autores:	Chunxia Gan, Titi Liu, Fei Chen, Jin Li, Jing Xu, Zhe Jiang, Hongkang Zhu, Chaoyi Xue, Jun Sheng, Huanhuan Xu
格式:	Artigo
語言:	Inglês
出版:	Tsinghua University Press 2026-03-01
叢編:	Food Science and Human Wellness
主題:	tumor necrosis factor-α (tnf-α) tnf-α receptor (tnfr) tnf-α-tnfr interaction nuclear factor–kappa b signaling rheumatoid arthritis
在線閱讀:	https://www.sciopen.com/article/10.26599/FSHW.2025.9250909
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