TNF stimulation primarily modulates transcriptional burst size of NF‐κB‐regulated genes

Abstract Cell‐to‐cell heterogeneity is a feature of the tumor necrosis factor (TNF)‐stimulated inflammatory response mediated by the transcription factor NF‐κB, motivating an exploration of the underlying sources of this noise. Here, we combined single‐transcript measurements with computational mode...

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Hlavní autoři:	Victor L Bass, Victor C Wong, M Elise Bullock, Suzanne Gaudet, Kathryn Miller‐Jensen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2021-07-01
Edice:	Molecular Systems Biology
Témata:	inflammation NF‐κB TNF transcriptional bursting
On-line přístup:	https://doi.org/10.15252/msb.202010127
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