High Fat Diet-Induced Hepatic 18-Carbon Fatty Acids Accumulation Up-Regulates CYP2A5/CYP2A6 via NF-E2-Related Factor 2

To investigate the role of hepatic 18-carbon fatty acids (FA) accumulation in regulating CYP2A5/2A6 and the significance of Nrf2 in the process during hepatocytes steatosis, Nrf2-null, and wild type mice fed with high-fat diet (HFD), and Nrf2 silenced or over expressed HepG2 cells administered with...

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Principais autores:	Xing-he Wang, Xiao-xu Cui, Xiao-qi Sun, Xing-hui Wang, Xiao-chong Li, Yue Qi, Wei Li, Mei-yu Han, Ishfaq Muhammad, Xiu-ying Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2017-05-01
Colecção:	Frontiers in Pharmacology
Assuntos:	18-carbon fatty acid CYP2A5 CYP2A6 Nrf2 high-fat diet hepatocyte steatosis
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fphar.2017.00233/full
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