CYP2D7 sequence variation interferes with TaqMan CYP2D6*15 and *35 genotyping

TaqMan™ genotyping assays are widely used to genotype CYP2D6, which encodes a major drug metabolizing enzyme. Assay design for CYP2D6 can be challenging owing to the presence of two pseudogenes, CYP2D7 and CYP2D8, structural and copy number variation and numerous single nucleotide polymorphisms (SNP...

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Principais autores:	Amanda K Riffel, Mehdi eDehghani, Toinette eHartshorne, Kristen eFloyd, J Steven eLeeder, Kevin P Rosenblatt, Andrea eGaedigk
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2016-01-01
Serija:	Frontiers in Pharmacology
Teme:	CYP2D6 genotyping TaqMan CYP2D7 CYP2D6*15 CYP2D6*35
Online dostop:	http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00312/full
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