Time to Amyloid Positivity and Preclinical Changes in Brain Metabolism, Atrophy, and Cognition: Evidence for Emerging Amyloid Pathology in Alzheimer's Disease

Background: Aβ pathology is associated with longitudinal changes of brain metabolism, atrophy, and cognition, in cognitively healthy elders. However, Aβ information is usually measured cross-sectionally and dichotomized to classify subjects as Aβ-positive or Aβ-negative, making it difficult to evalu...

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Detalhes bibliográficos

Principais autores:	Philip S. Insel, Rik Ossenkoppele, Devon Gessert, William Jagust, Susan Landau, Oskar Hansson, Michael W. Weiner, Niklas Mattsson, for the Alzheimer's Disease Neuroimaging Initiative
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2017-05-01
coleção:	Frontiers in Neuroscience
Assuntos:	Alzheimer's disease β-amyloid atrophy metabolism cognition preclinical
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fnins.2017.00281/full
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