Crystallographic data for Pyrococcus furiosus dolichylphosphate mannose synthase suggest that the enzyme could flip its glycolipid product

Abstract Dolichylphosphate mannose synthase (DPMS) performs an essential function by synthesizing the activated lipid-linked mannose intermediate used in protein glycosylation pathways. In eukaryotes and archaea, DPMS catalyzes the transfer of mannose from GDP-mannose to dolichylphosphate to generat...

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Hauptverfasser:	Rosaria Gandini, Markus M. Keskitalo, Tom Reichenbach, Dayanand C. Kalyani, Christina Divne
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2026-03-01
Schriftenreihe:	Scientific Reports
Online-Zugang:	https://doi.org/10.1038/s41598-026-44343-5
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