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Immune Profiles Identification by Vaccinomics After MVA Immunization in Randomized Clinical Study

BackgroundOur previous work has demonstrated the benefits of transcutaneous immunization in targeting Langerhans cells and preferentially inducing CD8 T-cell responses.MethodsIn this randomized phase Ib clinical trial including 20 HIV uninfected volunteers, we compared the safety and immunogenicity...

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Principais autores: Jorge Sanchez, Elena Gonçalves, Anuska Llano, Pedro Gonzáles, María Fernández-Maldonado, Annika Vogt, Angele Soria, Susana Perez, Samandhy Cedeño, Marco Antonio Fernández, Julien Nourikyan, Simon de Bernard, Carmela Ganoza, Eric Pedruzzi, Olivia Bonduelle, Beatriz Mothe, Carmen E. Gòmez, Mariano Esteban, Felipe Garcia, Javier R. Lama, Christian Brander, Behazine Combadiere
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-11-01
coleção:Frontiers in Immunology
Assuntos:
immunogenicity
cutaneous vaccination
intramuscular route
vaccinia virus vector
transcriptome
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2020.586124/full
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