Antigen Production After Latency Reversal and Expression of Inhibitory Receptors in CD8+ T Cells Limit the Killing of HIV-1 Reactivated Cells

The so-called shock and kill therapies aim to combine HIV-1 reactivation by latency-reversing agents (LRA) with immune clearance to purge the HIV-1 reservoir. The clinical use of LRA has demonstrated detectable perturbations in the HIV-1 reservoir without measurable reductions to date. Consequently,...

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Κύριοι συγγραφείς:	Alba Ruiz, Oscar Blanch-Lombarte, Esther Jimenez-Moyano, Dan Ouchi, Beatriz Mothe, Ruth Peña, Cristina Galvez, Meritxell Genescà, Javier Martinez-Picado, Philip Goulder, Richard Barnard, Bonnie Howell, Bonaventura Clotet, Julia G. Prado
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2019-01-01
Σειρά:	Frontiers in Immunology
Θέματα:	human immunodeficiency virus HIV-1 reservoir HIV-1 immunogen shock and kill CTL (Cytotoxic T lymphocyte) inhibitory receptors
Διαθέσιμο Online:	https://www.frontiersin.org/article/10.3389/fimmu.2018.03162/full
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