RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA

Abstract Background E3 ubiquitin ligases are established regulators of osteoarthritis pathogenesis known to amplify inflammatory signals via substrate protein destabilization, but their role in temporomandibular joint osteoarthritis (TMJOA) remains elusive. Methods This study investigated the impact...

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Hauptverfasser:	Xinjian Zhang, Qingkun Jiang, Wei Deng, Hai Tang, Yang Liu, Zichen Xu, Ke Guo, Ning Liu, Haitao Wang, Tiehan Cui, Fang Wang, Jiaxuan Qiu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-12-01
Schriftenreihe:	Arthritis Research & Therapy
Schlagworte:	TMJOA E3 ubiquitin ligases RNF152 HSP27 Fibroblast-like synoviocytes PI3K/AKT signalling pathway
Online-Zugang:	https://doi.org/10.1186/s13075-025-03715-4
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