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RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA

Abstract Background E3 ubiquitin ligases are established regulators of osteoarthritis pathogenesis known to amplify inflammatory signals via substrate protein destabilization, but their role in temporomandibular joint osteoarthritis (TMJOA) remains elusive. Methods This study investigated the impact...

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Principais autores: Xinjian Zhang, Qingkun Jiang, Wei Deng, Hai Tang, Yang Liu, Zichen Xu, Ke Guo, Ning Liu, Haitao Wang, Tiehan Cui, Fang Wang, Jiaxuan Qiu
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-12-01
Serier:Arthritis Research & Therapy
Fag:
TMJOA
E3 ubiquitin ligases
RNF152
HSP27
Fibroblast-like synoviocytes
PI3K/AKT signalling pathway
Online adgang:https://doi.org/10.1186/s13075-025-03715-4
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