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Schlafen 11 as a prognostic and potentially predictive biomarker in soft tissue sarcoma: evidence from a real-world cohort

BackgroundSoft tissue sarcomas (STS) carry a high risk of relapse or metastasis even after complete resection. (Neo-)adjuvant chemotherapy benefits only a subset of patients, underscoring the need for predictive biomarkers. Schlafen 11 (SLFN11) has emerged as a marker of sensitivity to DNA-damaging...

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Principais autores: Adrian Georg Simon, Su Ir Lyu, David Stahl, Lars Mortimer Schiffmann, Birte Wenk, Reinhard Buettner, Nora Wuerdemann, Armin Tuchscherer, Roland Tillmann Ullrich, Alexander Quaas
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2026-03-01
Series:Frontiers in Oncology
Assuntos:
soft tissue sarcoma
Schlafen 11
SLFN11
predictive biomarker
prognostic biomarker
trabectedin
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fonc.2026.1792367/full
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