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The CSF1+ tumor cell–SPP1+ macrophage axis drives gastric cancer progression and immunotherapy resistance

BackgroundGastric cancer (GC) remains a leading cause of global cancer mortality, characterized by profound heterogeneity. While immune checkpoint blockade (ICB) has emerged as a promising strategy, pervasive resistance frequently limits its clinical efficacy. Elucidating the mechanisms driving this...

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Váldodahkkit: Heng Zhang, Yundong You, Jinhao Peng, Qinhao Du, Xifan Liu
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Frontiers Media S.A. 2026-06-01
Ráidu:Frontiers in Immunology
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Liŋkkat:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1817573/full
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