Single-cell profiling reveals FAM117A as a key regulator linking macrophage–epithelial crosstalk with the progression of lung adenocarcinoma

Abstract The tumor microenvironment (TME) has a profound influence on the progression of lung adenocarcinoma (LUAD) and its response to therapy. We identified a tumor-promoting communication network based on single-cell RNA sequencing. This shows an SPP1 + macrophage and basal epithelial cell commun...

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Detalhes bibliográficos

Principais autores:	Chao Wu, Zhipeng Ren, Gang Che, Hui Liu, Haitao Tao, Dan Li, Jinliang Wang, Xiaobin Hou, Yi Hu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-02-01
coleção:	Experimental Hematology & Oncology
Assuntos:	Lung adenocarcinoma SPP1 + macrophage FAM117A Cell–cell communication Tumor microenvironment
Acesso em linha:	https://doi.org/10.1186/s40164-026-00745-9
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