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Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes

Group III metabotropic glutamate (mGlu) receptors mediate important neuroprotective and anti-inflammatory effects. Stimulation of mGlu4 receptor reduces neuroinflammation in a mouse model of experimental autoimmune encephalomyelitis (EAE) whereas mGlu4 knockout mice display exacerbated EAE clinical...

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Principais autores: Simona Federica Spampinato, Sara eMerlo, Mariangela eChisari, Ferdinando eNicoletti, Maria Angela eSortino
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2015-01-01
Serier:Frontiers in Cellular Neuroscience
Fag:
Astrocytes
Multiple Sclerosis
Transforming Growth Factor beta
Experimental autoimmune encephalomyelitis
oligodendrocytes
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00462/full
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