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Herpes Simplex Virus Type 2 Blocks IFN-β Production through the Viral UL24 N-Terminal Domain-Mediated Inhibition of IRF-3 Phosphorylation

Herpes simplex virus type 2 (HSV-2) is a sexually transmitted virus, the cause of genital herpes, and its infection can increase the risk of HIV-1 infection. After initial infection, HSV-2 can establish lifelong latency within the nervous system, which is likely associated with the virus-mediated im...

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Principais autores: Binman Zhang, Yuncheng Li, Ping Yang, Siyu He, Weilin Li, Miaomiao Li, Qinxue Hu, Mudan Zhang
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-10-01
Serier:Viruses
Fag:
HSV-2
UL24
IFN-β
IRF-3
immune evasion
Online adgang:https://www.mdpi.com/1999-4915/16/10/1601
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