Synthesis of cholera toxin B subunit glycoconjugates using site-specific orthogonal oxime and sortase ligation reactions

The chemoenzymatic synthesis of a series of dual N- and C-terminal–functionalized cholera toxin B subunit (CTB) glycoconjugates is described. Mucin 1 peptides bearing different levels of Tn antigen glycosylation [MUC1(Tn)] were prepared via solid-phase peptide synthesis. Using sortase-mediated ligat...

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Principais autores:	Jonathan P. Dolan, Darren C. Machin, Simone Dedola, Robert A. Field, Michael E. Webb, W. Bruce Turnbull
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-09-01
coleção:	Frontiers in Chemistry
Assuntos:	sortase glycopeptide glycoconjugates oxime ligation protein modification transpeptidase
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fchem.2022.958272/full
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