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Therapeutic Targeting of Aristolochic Acid Induced Uremic Toxin Retention, SMAD 2/3 and JNK/ERK Pathways in Tubulointerstitial Fibrosis: Nephroprotective Role of Propolis in Chronic Kidney Disease

The nephrotoxicity of aristolochic acids (AAs), p-cresyl sulfate (PCS) and indoxyl sulfate (IS) were well-documented, culminating in tubulointerstitial fibrosis (TIF), advanced chronic kidney disease (CKD) and fatal urothelial cancer. Nonetheless, information regarding the attenuation of AAs-induced...

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Principais autores: Jia-Feng Chang, Chih-Yu Hsieh, Kuo-Cheng Lu, Yue-Wen Chen, Shih-Shin Liang, Chih-Cheng Lin, Chi-Feng Hung, Jian-Chiun Liou, Mai-Szu Wu
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-06-01
Serier:Toxins
Fag:
aristolochic acid
uremic toxins
propolis extract
tubulointerstitial fibrosis
transforming growth factor-β
chronic kidney disease
Online adgang:https://www.mdpi.com/2072-6651/12/6/364
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