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EVATRAN (The Effect of Eplerenone on the Evolution of Vasculopathy in Renal Transplant Patients): study protocol for a cross-over randomized controlled trial

Abstract Background Arterial stiffness is a major prognostic factor of cardiovascular (CV) morbi-mortality in kidney transplant (KT) patients. Preclinical studies have demonstrated that the vascular toxicity of calcineurin inhibitors (CNI) is mediated through the activation of the mineralocorticoid...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Arnaud Simon, Nicolas Girerd, Frédéric Jaisser, Erwan Bozec, Xavier Lepage, Ludovic Mercklé, Patrick Rossignol, Luc Frimat, Sophie Girerd
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2025-11-01
Schriftenreihe:Trials
Schlagworte:
Eplerenone
Mineralocorticoid antagonist
Pulse wave velocity
Arterial stiffness
Cyclosporine
Calcineurin inhibitor
Online-Zugang:https://doi.org/10.1186/s13063-025-09187-w
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