Development of a Resistance-like Phenotype to Sorafenib by Human Hepatocellular Carcinoma Cells Is Reversible and Can Be Delayed by Metronomic UFT Chemotherapy

Acquired resistance to antiangiogenic drugs, such as sorafenib, is a major clinical problem. We studied development of a resistance to sorafenib in new preclinical models of human hepatocellular carcinoma (HCC) along with a strategy to delay such resistance—combination with metronomic chemotherapy....

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Bibliografische Detailangaben

Hauptverfasser:	Terence C. Tang, Shan Man, Ping Xu, Giulio Francia, Kae Hashimoto, Urban Emmenegger, Robert S. Kerbel
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2010-11-01
Schriftenreihe:	Neoplasia: An International Journal for Oncology Research
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S1476558610800417
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