Rapamycin treatment ameliorates HLA-B27-mediated gut inflammation and alters the microbiome in experimental spondyloarthritis

ObjectiveTo determine whether rapamycin affects HLA-B27-mediated gut inflammation in experimental spondyloarthritis (SpA).MethodsHLA-B27/human β2-microglobulin transgenic (B27-Tg) rats with gut inflammation were treated with rapamycin (1.5 mg/kg intraperitoneally, 3 times a week) or vehicle for 5 we...

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Autori principali:	Jinny Van Doorn, Stephen R. Brooks, Francesca LiCausi, Kelly Zhou, Naga S. Betrapally, Eva Gubitz-Hess, Antony Cougnoux, Stefania Dell’Orso, Shamima Islam, Robert A. Colbert, Fatemeh Navid
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-03-01
Serie:	Frontiers in Immunology
Soggetti:	gut inflammation HLA-B27 IL-17 rapamycin spondyloarthritis
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1755132/full
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