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Rapamycin treatment ameliorates HLA-B27-mediated gut inflammation and alters the microbiome in experimental spondyloarthritis

ObjectiveTo determine whether rapamycin affects HLA-B27-mediated gut inflammation in experimental spondyloarthritis (SpA).MethodsHLA-B27/human β2-microglobulin transgenic (B27-Tg) rats with gut inflammation were treated with rapamycin (1.5 mg/kg intraperitoneally, 3 times a week) or vehicle for 5 we...

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Principais autores: Jinny Van Doorn, Stephen R. Brooks, Francesca LiCausi, Kelly Zhou, Naga S. Betrapally, Eva Gubitz-Hess, Antony Cougnoux, Stefania Dell’Orso, Shamima Islam, Robert A. Colbert, Fatemeh Navid
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-03-01
Serier:Frontiers in Immunology
Fag:
gut inflammation
HLA-B27
IL-17
rapamycin
spondyloarthritis
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1755132/full
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