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GIRK2 potassium channels expressed by the AgRP neurons decrease adiposity and body weight in mice.

It is well known that the neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase appetite and decrease thermogenesis. Previous studies demonstrated that optogenetic and/or chemogenetic manipulations of NPY/AgRP neuronal activity alter food intake and/or energy expenditure (EE). However,...

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Autori principali: Youjin Oh, Eun-Seon Yoo, Sang Hyeon Ju, Eunha Kim, Seulgi Lee, Seyun Kim, Kevin Wickman, Jong-Woo Sohn
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2023-08-01
Serie:PLoS Biology
Accesso online:https://doi.org/10.1371/journal.pbio.3002252
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