Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death

The deletion of the gene coding for poly(ADPribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson’s disease. In sharp contrast, PARP1 inhibitors are in clinical use for the eradication of vulnerable cancer cells. It appears that excessiv...

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Bibliografiske detaljer

Principais autores:	Maria Castedo, Antoine Lafarge, Guido Kroemer
Format:	Artigo
Sprog:	Inglês
Udgivet:	Shared Science Publishers OG 2023-01-01
Serier:	Cell Stress
Fag:	parp1 inhibition dna damage parthanatos cancer neurological diseases aging cellular stress response
Online adgang:	http://www.cell-stress.com/researcharticles/2023a-castedo-cell-stress/
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