Reduction in pericyte coverage leads to blood–brain barrier dysfunction via endothelial transcytosis following chronic cerebral hypoperfusion

Abstract Background Chronic cerebral hypoperfusion (CCH) is the leading cause of cerebral small vessel disease (CSVD). CCH is strongly associated with blood–brain barrier (BBB) dysfunction and white matter lesions (WMLs) in CSVD. However, the effects of CCH on BBB integrity and components and the ce...

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Váldodahkkit:	Zhengyu Sun, Chenhao Gao, Dandan Gao, Ruihua Sun, Wei Li, Fengyu Wang, Yanliang Wang, Huixia Cao, Guoyu Zhou, Jiewen Zhang, Junkui Shang
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	BMC 2021-05-01
Ráidu:	Fluids and Barriers of the CNS
Fáttát:	Cerebral small vessel disease Chronic cerebral hypoperfusion BBB permeability BBB protection Pericyte Endothelial transcytosis
Liŋkkat:	https://doi.org/10.1186/s12987-021-00255-2
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