Caveolin1 Is Required for Th1 Cell Infiltration, but Not Tight Junction Remodeling, at the Blood-Brain Barrier in Autoimmune Neuroinflammation

Lymphocytes cross vascular boundaries via either disrupted tight junctions (TJs) or caveolae to induce tissue inflammation. In the CNS, Th17 lymphocytes cross the blood-brain barrier (BBB) before Th1 cells; yet this differential crossing is poorly understood. We have used intravital two-photon imagi...

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Bibliografiska uppgifter

Huvudupphov:	Sarah E. Lutz, Julian R. Smith, Dae Hwan Kim, Carl V.L. Olson, Kyle Ellefsen, Jennifer M. Bates, Sunil P. Gandhi, Dritan Agalliu
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Elsevier 2017-11-01
Serie:	Cell Reports
Ämnen:	multiple sclerosis experimental autoimmune encephalomyelitis blood-brain barrier endothelium tight junction caveolae transcytosis Claudin5 Caveolin1 intravital microscopy
Länkar:	http://www.sciencedirect.com/science/article/pii/S2211124717315747
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