Cytotoxic CD4+ T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate Trypanosoma cruzi-infected hearts

Increasing attention has been directed to cytotoxic CD4+ T cells (CD4CTLs) in different pathologies, both in humans and mice. The impact of CD4CTLs in immunity and the mechanisms controlling their generation, however, remain poorly understood. Here, we show that CD4CTLs abundantly differentiate duri...

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Ngā kaituhi matua:	Carlos-Henrique D Barbosa, Fábio B Canto, Ariel Gomes, Layza M Brandao, Jéssica R Lima, Guilherme A Melo, Alessandra Granato, Eula GA Neves, Walderez O Dutra, Ana-Carolina Oliveira, Alberto Nóbrega, Maria Bellio
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	eLife Sciences Publications Ltd 2022-06-01
Rangatū:	eLife
Ngā marau:	cytotoxicity CD4 T cells infectious disease myocarditis Chagas disease MyD88
Urunga tuihono:	https://elifesciences.org/articles/74636
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!