Cytotoxic CD4+ T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate Trypanosoma cruzi-infected hearts

Increasing attention has been directed to cytotoxic CD4+ T cells (CD4CTLs) in different pathologies, both in humans and mice. The impact of CD4CTLs in immunity and the mechanisms controlling their generation, however, remain poorly understood. Here, we show that CD4CTLs abundantly differentiate duri...

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Hlavní autoři:	Carlos-Henrique D Barbosa, Fábio B Canto, Ariel Gomes, Layza M Brandao, Jéssica R Lima, Guilherme A Melo, Alessandra Granato, Eula GA Neves, Walderez O Dutra, Ana-Carolina Oliveira, Alberto Nóbrega, Maria Bellio
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	eLife Sciences Publications Ltd 2022-06-01
Edice:	eLife
Témata:	cytotoxicity CD4 T cells infectious disease myocarditis Chagas disease MyD88
On-line přístup:	https://elifesciences.org/articles/74636
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