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A novel synthetic oleanane triterpenoid, 2‐cyano‐3,12‐dioxoolean‐1,9‐dien‐28‐oic acid, regulates mechanical allodynia by rescuing neuronal cell death and glial cell activation in the spinal cord of resiniferatoxin‐treated rats

Abstract Background Treating postherpetic neuralgia (PHN), which is characterized with a long‐lasting lancinating mechanical allodynia or hyperalgesia, is a big challenge as it is hard to achieve complete resolution. A synthetic triterpenoid, CDDO (2‐cyano‐3,12‐dioxoolean‐1,9‐dien‐28‐oic acid) can e...

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Gespeichert in:
Hauptverfasser: Ying‐Yi Lu, Chia‐Yang Lin, Hung‐Pei Tsai, Chih‐Lung Lin, Chieh‐Hsin Wu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wiley 2024-02-01
Schriftenreihe:Brain and Behavior
Schlagworte:
2‐cyano‐3,12‐dioxoolean‐1,9‐dien‐28‐oic acid
mechanical allodynia
resiniferatoxin
triterpenoid
Online-Zugang:https://doi.org/10.1002/brb3.3398
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