Enzyme-mediated alkynylation enables transcriptome-wide identification of pseudouridine modifications

Abstract Pseudouridine (Ψ) is one of the most abundant chemical modifications and plays important roles in RNA function. Advances in our understanding of Ψ have been hindered by a limit of robust methods to precisely and sensitively map their distributions in cellular RNAs. Here, we present ELAP-seq...

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Detalhes bibliográficos

Principais autores:	Yuru Wang, Kinga Pajdzik, Yutao Zhao, Chang Ye, Talbot Stone, Li-Sheng Zhang, Wen Zhang, Mahdi Assari, Wenxin Zhao, Caraline Sepich-Poore, Qing Dai, Ke Wang, Minkui Luo, Tao Pan, Chuan He
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-03-01
Colecção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-026-70597-8
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