Integrated single-cell and transcriptomic profiling identifies machine-learning–based pyroptosis biomarkers in IBD

BackgroundPyroptosis, an inflammatory form of programmed cell death, contributes to intestinal inflammation in inflammatory bowel disease (IBD), but the key cell types and regulatory genes remain unclear.MethodsWe analyzed single-cell RNA-seq data from intestinal mucosa to assess pyroptosis-related...

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Главные авторы:	Yao Lu, Yahui Lin, Yuansen Li, Huan Sai, Cheng Chen, Jinjiao Li
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2026-02-01
Серии:	Frontiers in Immunology
Предметы:	inflammatory bowel disease machine learning pyroptosis single-cell RNA sequencing transcriptomic integration
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1761476/full
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