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mTORC2 affects the maintenance of the muscle stem cell pool

Abstract Background The mammalian target of rapamycin complex 2 (mTORC2), containing the essential protein rictor, regulates cellular metabolism and cytoskeletal organization by phosphorylating protein kinases, such as PKB/Akt, PKC, and SGK. Inactivation of mTORC2 signaling in adult skeletal muscle...

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Autores principales: Nathalie Rion, Perrine Castets, Shuo Lin, Leonie Enderle, Judith R. Reinhard, Markus A. Rüegg
Formato: Artigo
Lenguaje:Inglês
Publicado: BMC 2019-12-01
Colección:Skeletal Muscle
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Acceso en línea:https://doi.org/10.1186/s13395-019-0217-y
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