Elevated levels of the polo kinase Cdc5 override the Mec1/ATR checkpoint in budding yeast by acting at different steps of the signaling pathway.

Checkpoints are surveillance mechanisms that constitute a barrier to oncogenesis by preserving genome integrity. Loss of checkpoint function is an early event in tumorigenesis. Polo kinases (Plks) are fundamental regulators of cell cycle progression in all eukaryotes and are frequently overexpressed...

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Autors principals:	Roberto Antonio Donnianni, Matteo Ferrari, Federico Lazzaro, Michela Clerici, Benjamin Tamilselvan Nachimuthu, Paolo Plevani, Marco Muzi-Falconi, Achille Pellicioli
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2010-01-01
Col·lecció:	PLoS Genetics
Accés en línia:	http://europepmc.org/articles/PMC2797610?pdf=render
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