Targeting METTL3 protein by proteolysis-targeting chimeras: A novel therapeutic approach for acute myeloid leukemia

Despite numerous studies suggesting that RNA m6A transferase core complex including METTL3 and METTL14 play essential roles in both the initiation and maintenance of acute myeloid leukemia (AML), effective pharmacological targeting of these two proteins remains elusive. Here, we report the developme...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Rukiye Nar, Zhixing Wu, Yafang Li, Alexis Smith, Yutao Zhang, Jue Wang, Fang Yu, Sanhui Gao, Chunjie Yu, Zhiguang Huo, Guangrong Zheng, Zhijian Qian
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	KeAi Communications Co., Ltd. 2025-07-01
Edice:	Genes and Diseases
Témata:	Acute myeloid leukemia METTL3 PROTAC Protein degradation ZW27941
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2352304224002496
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!