mRNAs encoding self-DNA reactive cGAS enhance the immunogenicity of lipid nanoparticle vaccines

ABSTRACTLipid nanoparticle (LNP)-encapsulated mRNAs have emerged as effective vaccination tools to stimulate immunity. The most common application of this technology is to deliver mRNAs that encode antigenic proteins to dendritic cells (DCs), which then stimulate antigen-specific lymphocyte response...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Dania Zhivaki, Emily A. Gosselin, Debrup Sengupta, Holly Concepcion, Chisom Arinze, Jonathan Chow, Anastasia Nikiforov, Veronica Komoroski, Carolyn MacFarlane, Caitlin Sullivan, Jonathan C. Kagan
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	American Society for Microbiology 2023-12-01
Цуврал:	mBio
Нөхцлүүд:	vaccines cGAS innate immunity mRNA catalytic adjuvant adjuvants
Онлайн хандалт:	https://journals.asm.org/doi/10.1128/mbio.02506-23
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!