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mRNAs encoding self-DNA reactive cGAS enhance the immunogenicity of lipid nanoparticle vaccines

ABSTRACTLipid nanoparticle (LNP)-encapsulated mRNAs have emerged as effective vaccination tools to stimulate immunity. The most common application of this technology is to deliver mRNAs that encode antigenic proteins to dendritic cells (DCs), which then stimulate antigen-specific lymphocyte response...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Dania Zhivaki, Emily A. Gosselin, Debrup Sengupta, Holly Concepcion, Chisom Arinze, Jonathan Chow, Anastasia Nikiforov, Veronica Komoroski, Carolyn MacFarlane, Caitlin Sullivan, Jonathan C. Kagan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2023-12-01
Schriftenreihe:mBio
Schlagworte:
vaccines
cGAS
innate immunity
mRNA
catalytic adjuvant
adjuvants
Online-Zugang:https://journals.asm.org/doi/10.1128/mbio.02506-23
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