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Inhibiting stromal Class I HDACs curbs pancreatic cancer progression

Abstract Oncogenic lesions in pancreatic ductal adenocarcinoma (PDAC) hijack the epigenetic machinery in stromal components to establish a desmoplastic and therapeutic resistant tumor microenvironment (TME). Here we identify Class I histone deacetylases (HDACs) as key epigenetic factors facilitating...

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Principais autores: Gaoyang Liang, Tae Gyu Oh, Nasun Hah, Hervé Tiriac, Yu Shi, Morgan L. Truitt, Corina E. Antal, Annette R. Atkins, Yuwenbin Li, Cory Fraser, Serina Ng, Antonio F. M. Pinto, Dylan C. Nelson, Gabriela Estepa, Senada Bashi, Ester Banayo, Yang Dai, Christopher Liddle, Ruth T. Yu, Tony Hunter, Dannielle D. Engle, Haiyong Han, Daniel D. Von Hoff, Michael Downes, Ronald M. Evans
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Portfolio 2023-12-01
סדרה:Nature Communications
גישה מקוונת:https://doi.org/10.1038/s41467-023-42178-6
תגים: הוספת תג
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