Phase IB trial of high dose ascorbic acid + nab-paclitaxel + cisplatin + gemcitabine in patients with untreated metastatic pancreatic cancer

Background: Preclinical studies suggest that cancer cells take up oxidized vitamin C (dehydroascorbate, DHA) via the GLUT1 transporter, leading to oxidative stress and glutathione depletion. This mechanism may offer a therapeutic strategy for KRAS-mutated cancers. This Phase IB trial evaluated high-...

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Bibliografiske detaljer

Principais autores:	Gayle S. Jameson, S. Danielle LeGrand, Michael S. Gordon, Denise J. Roe, Betsy C. Wertheim, Kellen Olszewski, Josh Rabinowitz, Ron Evans, Michael Downes, Morgan Truitt, Ron Korn, Haiyong Han, Richard M. Miller, Michael T. Barrett, David Propper, Daniel D. Von Hoff, Erkut Borazanci
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2025-12-01
Serier:	Redox Biology
Fag:	Untreated metastatic pancreatic adenocarcinoma Ascorbic acid + nab-paclitaxel + cisplatin + gemcitabine Pancreatic ductal adenocarcinoma Clinical trial
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2213231725004082
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