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Cyclophilin B deficiency enhances myocardial energy synthesis and protects against heart failure in preclinical models

Abstract Background Heart failure (HF) represents the end stage of cardiovascular diseases with high mortality and limited treatment options. Cyclophilin B (CypB), known mainly as an endoplasmic reticulum chaperone, has been implicated in cardiovascular diseases. But the role of CypB in HF remains u...

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Hlavní autoři: Xiao Zong, Xierenayi Tudi, Qian Yang, Lingfang Zhuang, Roubai Pan, Qin Fan, Rong Tao
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2025-12-01
Edice:BMC Medicine
Témata:
Heart failure
Cardiac hypertrophy
Cyclophilin B
Metabolism
STAT3
On-line přístup:https://doi.org/10.1186/s12916-025-04563-4
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