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A Core Transcription Regulatory Circuitry Defining Microglia Cell Identity Inferred from the Reanalysis of Multiple Human Microglia Differentiation Protocols

Microglia, the immune cells in the brain involved in both homeostasis and injury/infection control, play a predominant role in neurodegenerative diseases. In vivo studies on microglia are limited due to the requirement of surgical intervention, which can lead to the destruction of the tissues. Over...

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Principais autores: Antoine Aubert, François Stüder, Bruno Maria Colombo, Marco Antonio Mendoza-Parra
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2021-10-01
סדרה:Brain Sciences
נושאים:
microglia differentiation
transcriptomics
gene regulatory networks
systems biology
גישה מקוונת:https://www.mdpi.com/2076-3425/11/10/1338
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