IRF1 is a core transcriptional regulatory circuitry member promoting AML progression by regulating lipid metabolism

Abstract Background Acute myeloid leukemia (AML) is a prevalent malignancy of the hematologic system. Despite advancements in therapeutic approaches, significant heterogeneity and therapeutic resistance pose substantial challenges to treatment. Tumors driven by core transcription factors through sup...

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Ngā kaituhi matua:	Fenli Zhang, Zhiheng Li, Fang Fang, Yixin Hu, Zhixu He, Yanfang Tao, Yizhen Li, Zimu Zhang, Bi Zhou, Ying Yang, Yumeng Wu, Yijun Wu, Zhongling Wei, Ailian Guo, Ling Xu, Yongping Zhang, Xiaolu Li, Yan Li, Chunxia Yang, Man Zhou, Jian Pan, Shaoyan Hu, Xiaoyan Yang
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2025-03-01
Rangatū:	Experimental Hematology & Oncology
Ngā marau:	IRF1 AML Core transcriptional regulatory circuit Super-enhancer Lipid metabolism
Urunga tuihono:	https://doi.org/10.1186/s40164-025-00612-z
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!