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Aberrant overexpression of HOTAIR inhibits abdominal adipogenesis through remodelling of genome-wide DNA methylation and transcription

Objective: Abdominal adiposity is strongly associated with diabetic and cardiovascular comorbidities. The long noncoding RNA HOTAIR (HOX Transcript Antisense Intergenic RNA) is an important epigenetic regulator with fat depot-specific expression. Its functional roles and epigenetic regulation in abd...

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Principais autores: Feng-Chih Kuo, Yu-Chun Huang, Ming-Ren Yen, Chien-Hsing Lee, Kuo-Feng Hsu, Hsiang-Yu Yang, Li-Wei Wu, Chieh-Hua Lu, Yu-Juei Hsu, Pao-Yang Chen
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2022-06-01
Serier:Molecular Metabolism
Fag:
lncRNA
HOTAIR
Subcutaneous adipose tissue
Visceral adipose tissue
Abdominal adipogenesis
Epigenetic regulation
Online adgang:http://www.sciencedirect.com/science/article/pii/S2212877822000424
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