IDH2/R140Q mutation confers cytokine-independent proliferation of TF-1 cells by activating constitutive STAT3/5 phosphorylation

Abstract Background R140Q mutation in isocitrate dehydrogenase 2 (IDH2) promotes leukemogenesis. Targeting IDH2/R140Q yields encouraging therapeutic effects in the clinical setting. However, therapeutic resistance occurs in 12% of IDH2/R140Q inhibitor treated patients. The IDH2/R140Q mutant converte...

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Detalhes bibliográficos

Principais autores:	Jie Yang, Jiao Chen, Jingjie Chang, Xiaoyan Sun, Qingyun Wei, Xueting Cai, Peng Cao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-02-01
coleção:	Cell Communication and Signaling
Assuntos:	Acute myeloid leukemia Isocitrate dehydrogenase 2 R140Q mutation Cytokine-independent proliferation Signal transducer and activator of transcription 3/5
Acesso em linha:	https://doi.org/10.1186/s12964-023-01367-y
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