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Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

ABSTRACT Aristolochic acids (AAs) are natural compounds found in Aristolochiaceae plants, to which humans are frequently exposed through environmental and medicinal sources. AAs are highly nephrotoxic and carcinogenic, mediated by oxidative stress and bioactivation‐induced DNA damage and mutagenicit...

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Principais autores: Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-04-01
Serier:Advanced Science
Fag:
antioxidant
Aristolochiaceae
butterflies
chemical defense
DNA repair
multiomics
Online adgang:https://doi.org/10.1002/advs.202518072
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