QR-Code

Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues

Abstract Senescent cells drive age-related tissue dysfunction via the induction of a chronic senescence-associated secretory phenotype (SASP). The cyclin-dependent kinase inhibitors p21Cip1 and p16Ink4a have long served as markers of cellular senescence. However, their individual roles remain incomp...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Dominik Saul, Diana Jurk, Madison L Doolittle, Robyn Laura Kosinsky, Yeaeun Han, Xu Zhang, Ana Catarina Franco, Sung Y Kim, Saranya P Wyles, Y S Prakash, David G Monroe, Luigi Ferrucci, Nathan K LeBrasseur, Paul D Robbins, Laura J Niedernhofer, Sundeep Khosla, João F Passos
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Nature 2025-10-01
Schriftenreihe:The EMBO Journal
Schlagworte:
Cellular Senescence
Senescence-Associated Secretory Phenotype (SASP)
Heterogeneity
Single-Cell Mapping
Aging
Online-Zugang:https://doi.org/10.1038/s44318-025-00601-2
Tags: Tag hinzufügen
Keine Tags, Fügen Sie das erste Tag hinzu!

Ähnliche Einträge