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Rapamycin improves peripheral nerve myelination while it fails to benefit neuromuscular performance in neuropathic mice

Charcot–-Marie–Tooth disease type 1A (CMT1A) is a hereditary peripheral neuropathy characterized by progressive demyelination and distal muscle weakness. Abnormal expression of peripheral myelin protein 22 (PMP22) has been linked to CMT1A and is modeled by Trembler J (TrJ) mice, which carry the same...

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Hoofdauteurs: Jessica Nicks, Sooyeon Lee, Andrew Harris, Darin J. Falk, Adrian G. Todd, Karla Arredondo, William A. Dunn, Jr., Lucia Notterpek
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2014-10-01
Reeks:Neurobiology of Disease
Onderwerpen:
Demyelination
Autophagy
Schwann cell
Myelin
Trembler J
Charcot–Marie–Tooth disease
Online toegang:http://www.sciencedirect.com/science/article/pii/S0969996114001879
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