The formation of peripheral myelin protein 22 aggregates is hindered by the enhancement of autophagy and expression of cytoplasmic chaperones

The accumulation of misfolded proteins is associated with various neurodegenerative conditions. Peripheral myelin protein 22 (PMP22) is a hereditary neuropathy-linked, short-lived molecule that forms aggresomes when the proteasome is inhibited or the protein is mutated. We previously showed that the...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Jenny Fortun, Jonathan D. Verrier, Jocelyn C. Go, Irina Madorsky, William A. Dunn, Lucia Notterpek
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2007-02-01
Schriftenreihe:	Neurobiology of Disease
Schlagworte:	Autophagosome Proteasome Neuropathy Schwann cells Protein misfolding Aggresomes
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S096999610600235X
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