A Bioengineered Neuregulin-Hydrogel Therapy Reduces Scar Size and Enhances Post-Infarct Ventricular Contractility in an Ovine Large Animal Model

The clinical efficacy of neuregulin (NRG) in the treatment of heart failure is hindered by off-target exposure due to systemic delivery. We previously encapsulated neuregulin in a hydrogel (HG) for targeted and sustained myocardial delivery, demonstrating significant induction of cardiomyocyte proli...

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Bibliografski detalji

Glavni autori:	Jeffrey E. Cohen, Andrew B. Goldstone, Hanjay Wang, Brendan P. Purcell, Yasuhiro Shudo, John W. MacArthur, Amanda N. Steele, Michael J. Paulsen, Bryan B. Edwards, Chiaka N. Aribeana, Nicholas C. Cheung, Jason A. Burdick, Y. Joseph Woo
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2020-11-01
Serija:	Journal of Cardiovascular Development and Disease
Teme:	neuregulin hydrogel myocardial infarction ischemic heart failure
Online pristup:	https://www.mdpi.com/2308-3425/7/4/53
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