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A Bioengineered Neuregulin-Hydrogel Therapy Reduces Scar Size and Enhances Post-Infarct Ventricular Contractility in an Ovine Large Animal Model

The clinical efficacy of neuregulin (NRG) in the treatment of heart failure is hindered by off-target exposure due to systemic delivery. We previously encapsulated neuregulin in a hydrogel (HG) for targeted and sustained myocardial delivery, demonstrating significant induction of cardiomyocyte proli...

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Principais autores: Jeffrey E. Cohen, Andrew B. Goldstone, Hanjay Wang, Brendan P. Purcell, Yasuhiro Shudo, John W. MacArthur, Amanda N. Steele, Michael J. Paulsen, Bryan B. Edwards, Chiaka N. Aribeana, Nicholas C. Cheung, Jason A. Burdick, Y. Joseph Woo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-11-01
coleção:Journal of Cardiovascular Development and Disease
Assuntos:
neuregulin
hydrogel
myocardial infarction
ischemic heart failure
Acesso em linha:https://www.mdpi.com/2308-3425/7/4/53
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