Upregulated Ca²⁺ Release from the Endoplasmic Reticulum Leads to Impaired Presynaptic Function in Familial Alzheimer’s Disease

Neurotransmitter release from presynaptic terminals is primarily regulated by rapid Ca²⁺ influx through membrane-resident voltage-gated Ca²⁺ channels (VGCCs). Moreover, accumulating evidence indicates that the endoplasmic reticulum (ER) is extensively present in axonal terminal...

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Autors principals:	Temitope Adeoye, Syed I. Shah, Angelo Demuro, David A. Rabson, Ghanim Ullah
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2022-07-01
Col·lecció:	Cells
Matèries:	neuronal calcium signaling endoplasmic reticulum Alzheimer’s IP<sub>3</sub>R neurotransmitter release synaptic transmission
Accés en línia:	https://www.mdpi.com/2073-4409/11/14/2167
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