The effects of apolipoprotein E genotype, α‐synuclein deficiency, and sex on brain synaptic and Alzheimer's disease–related pathology

Abstract Introduction Alzheimer's disease (AD) and synucleinopathies share common pathological mechanisms. Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for AD, also increases the risk for dementia in pure synucleinopathies. We presently examined the effects of α‐synuclein defici...

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Principais autores:	Roni Bar, Anat Boehm‐Cagan, Ishai Luz, Yarden Kleper‐Wall, Daniel M. Michaelson
格式:	Artigo
语言:	Inglês
出版:	Wiley 2018-01-01
丛编:	Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
主题:	Alzheimer's disease Apolipoprotein E4 (apoE4) apoE‐targeted replacement mice Sex α‐Synuclein deficiency
在线阅读:	https://doi.org/10.1016/j.dadm.2017.08.003
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